Autophagic Punctum
Autophagy, neuron-specific degradation and neurodegeneration
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Keywords: Drosophila, endocytic trafficking, neurodegeneration, SNARE, v-ATPase
Authors: Dong Wang and P. Robin Hiesinger
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Degradation of membrane compartments, organelles and other debris through macroautophagy (hereafter referred to as autophagy) is thought to occur in most, maybe all, cells. We recently reported the discovery of a neuron-specific endomembrane degradation mechanism that depends on the vesicle SNARE neuronal Synaptobrevin (n-Syb) and the vesicle ATPase component V100 (the V0a1 subunit). Loss of n-Syb causes degeneration of adult photoreceptor neurons in Drosophila, reminiscent of adult-onset degeneration in neurons with defective autophagy. Here we explore the potential importance of this newly discovered neuron-specific degradation mechanism in comparison with ubiquitous autophagy machinery for adult-onset neurodegeneration.
Autophagic Punctum to:
A Haberman, WR Williamson, D Epstein, D Wang, S Rina, IA Meinertzhagen, PR Hiesinger. The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration. J Cell Biol 2012; 196: 261-76
PMID: 22270918 DOI: 10.1083/jcb.201108088
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